It depends on what you are trying to do. If you're trying to resize it, there might be a possibility that it would not upload the edited version. Same goes if you are trying to change the file name.
Alternatively, you can let the original file upload and then just upload the edited and/or changed file as well, but you can add "edit" at the end of the file name.
Or you can just pause the uploading altogether and not have to deal with this. It's really up to you.