My network is now 3G-only (pretty much, as they have begun the shutdown of roaming on a rival's 2G network recently to cut down costs). So I am stuck with 3G.
On my TP2 I noticed that there wasn't a great deal of difference when using my current network on 3G-only, to using my previous network set to 2G-only (I mainly use Opera Mini, so used to turn the 3G off on the previous network for reliability, otherwise you'd sometimes get dropped calls as their 3G network is still lacking coverage a bit).
On my K800i however (yeah, I still use one lol) I get around 2 - 3 days standby when on 3G/2G and around a week or more (depends on use) when on 2G-only. When actually using the phone, there is a huge difference in battery life. So I'd say it depends on the phone - the worst you can do is try it, and see what happens. It won't break it hehe.