Can I play Borderlands 3 without playing the other games?

[Windows Central]

Best answer: Yes. While there will be some returning characters who you'll recognize from playing previous Borderlands games, and there will likely be references to past events, you'll still be able to follow the plot without playing other franchise entries. The game brings new villains, a new plot, and a new set of Vault Hunters.

Full story from the WindowsCentral blog...