How to solve the pesky "not designed to run on your OS" Visual C++ error

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Should you encounter an issue with some software or games where a specific file error shows up with "this is not designed to run on your OS," we're going to look at a few things you can try out to fix it.
The issue I had was with mfc140u.dll, which is part of Microsoft's Visual C++ redistribution suite, the 2015 version in my case. The GOG Galaxy client can sometimes stumble with this issue, which has caused gamers to take to online forums to try and get some assistance.

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