If you don't want Windows Defender Antivirus to keep quarantine items forever, you can use this guide to configure automatic removal after a specified number of days.
On Windows 10, when Windows Defender Antivirus can't fully determine if a suspicious file is infected, usually, it moves it to the Quarantine folder. This is a special location designed to isolate threats so that they can't harm your computer, or so you can restore false positives as necessary.
Full story from the WindowsCentral blog...
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