I'm a low ISO fanatic. Most shots with my 808 were at ISO 50. Now I am slightly irritated that lowest is 100 and that I can't save it as a default. O well..
I have a pretty steady hand and where that's impossible, I carry a gorilla grip tripod in my messenger bag (love how tripod-friendly the new camera grip is).
Point is, the difference in quality makes the small amount of hassle worth it IMO