I'm like 1jax. Did it everyday for a week or 2 and finally got settled it. I put mine it categories.
Top is the HTC live tile. Below that I have small tiles of my most used which is growing but right now its. Zune, Pageonce finance, Xbox, FB, Chrome to WP7, Me, YouTube, Netflix.
I use my pics tile as divider for the next group which is my phone, messaging, email accts and quick contacts. The next divider is the calendar tile. Below that I have my apps and or webpage short cuts that I use from time to time.