my HTC Titan reception is pretty crappy. Friday night, I was in a low-signal area and had no bars, but my wife's Samsung Focus (1st gen) had 1-2 bars.
On my way home from work, I get into a 3-5 mile area where I can't talk on the phone now. I used to have this problem with my iPhone 3GS, and then AT&T did something and it got better, so much so, that I could usually keep a call going the whole trip home. Now, I don't even bother. My phone is in a rubberized-gel case, but the case doesn't affect the signal. Also, the phone doesn't have to be held to have the signal drops.
I also hear complaints of people I'm talking to not being able to hear me. I'm wondering if the noise-canceling on the mics is affecting the call quality.
Otherwise, I love the Titan.