I essentially use different browsers for different accounts so I don't have to switch between them (Google's switcher is great, but Microsoft's not as quick).
Chrome gets the heaviest lifting including being logged in to my main work Office365 services, my main personal Outlook.com, and my main personal Google really only used for YouTube. The value of the extensions outweighs my general dislike of Google-y things.
Firefox I use for my independent small business and an online network I do a lot of tech work for, which is another Office365, another Outlook.com, and another Google account.
Edge I use to login to client Office365 services, e.g. building SharePoint sites. Sometimes IE for those odd features of SharePoint which only work in IE still.
I tried to make Opera the personal use browser when I first started this system but laziness ultimately kicked in and that merged with Chrome as the work browser since there weren't conflicting account types to worry about.