Great question, but the answer is YES. Since I was starting with a new phone, I updated, then reset, then started getting all my stuff moved from my BlackBerry Z10 to my 640... obviously, no back up to restore for me...
Still, it makes a great point, and more generally to all mobile devices or maybe even all devices at all, occasionally a complete wipe and start over with the very minimum of moving stuff into it (not restore) is the best way to clear all junk out.
Although it may be inconvenient for some, but starting fresh is always the best way to go if you truly want to experience W10M. Most people on this forum didn't realize this when they upgraded to W10M from WP8.1.
But in your case, coming from a BB10 shouldn't be a problem actually, since those who face problems on W10M are generally those who restored backups from WP8.1, and some how those back up kinda messes up with the new OS. But coming from a different ecosystem altogether? Not sure about that mate :amaze: