Oh yeah, everything works 100% perfectly. Location reminders, geofencing, etc. Even local recommendations (even though I turn that part off, it does work fine if you use it).
My settings are USA for everything.
LANGUAGE: "English (United States)"
Country/Region: "United States"
Regional format: "match phone language"
The only real pain is searching on maps. You have to be specific for things. Like instead of searching "102 centre street", you have to put "102 centre street, city, province". But I'm not sure if that's because my phone is set as an American phone, or just on account of Bing being very basic in searching compared to google.