Based on everything I did last night, I would say MS was at least correct when they told me there was a glitch with the ISO file. My guinea pig pc would not activate at any point. I spent most of the night Binging possible solutions and trying different things. As soon as I ran the sfc command, within seconds it activated. I am guessing whatever was holding up the activation was kick started by the sfc command. After successfully activating that pc, I went ahead and installed via the Media Creation Tool onto my primary pc. After installation, I had the same activation error. So I proceeded to run the sfc command and again within seconds I was able to activate.
Even managed to do a clean install over night with the first pc and had no issues with activation. Before you do the clean install, I would recommend downloading and installing Belarc Advisor. This will provide you the Windows 10 product key. Once you have the product key in hand, go head and do a clean install. The install process did ask me for the key. And, although, you can skip that page, and more than likely the key will come across as soon as you sign in with your Microsoft account, I didn't want to take a chance. I entered the key, went through the clean install process and Windows 10 was activated as soon as it finished installing.