There are several settings in WP that need to be improved:
Language and region need to be combined into a single control panel, so you don't have to restart your phone TWICE as you currently do - first to change the language and then to change the region. I guess a lot of people don't change their phone language or region very often, but for those of us who do, this is a real pain. And you should be able to select a language, rather than have to move it to the top of a list.
Once installed, all apps should update automatically to the latest version regardless of what language or region your phone is set to. And anyone who has apps from more than one country (e.g. newspaper apps) will run into this problem sooner or later. Some apps won't update until the phone is set to a particular system language/region/format. This is completely stupid, and a potential security risk by leaving buggy apps in place.
And (like in desktop Windows) there should be a way of choosing preferred date, time, paper, currency, and measurement formats without having to choose from a list of country settings. I'm happy with US English, but prefer the metric system, 24-hour time, and the 20 June 1999 long and 1999-06-20 short date formats, for example, but WP won't let me do this...